Estimation of Ibuprofen in Bulk and Tablets Using Ibuprofen Sodium as Hydrotropic Solubilizing Agent

摘要

In the present investigation,hydrotropic solubilization phenomenon has been employed to solubilize the poorly water-soluble antiinflammatory drug,ibuprofen by use of 0.5 M of ibuprofen sodium (an economic drug) solution to carry out titrimetric analysis (in bulk drug sample and tablets) precluding the use of organic solvents. The methods are new,simple,accurate,reproducible,inexpensive and eco-friendly. The results of analysis by proposed methods of analysis compared well with the results of standard pharmacopoeial methods. Recovery studies and statistical parameters validated the proposed methods.