Synthesis and Characterization of 1-Isonicotinoyl/1-Carboxamido/1-Thiocarboxamido-3-(2-hydroxy-5-chlorophenyl)-4-aroyl-3-methyl pyrazoles

摘要

Chromone,the starting material for the preparation of 3-methyl pyrazole,is prepared from 2-hydroxy-5-chloro dibenzoyl methane by the action of acetic anhydride and fused sodium acetate in an oil bath at 160 deg C for 30 min.1,4,5-Trisubstituted pyrazoles are obtained by refluxing the mixture of 3-benzoyl-2-methyl-6-chloro-chromone and nucleophiles sch as isonicotinic acid,semicarbazide and thiosemicarbazide in methanol medium.The structures are confirmed by IR and NMR spectral data.