Cyclization of 2'-Hydroxychalcones in Dimethyl Sulphoxide

摘要

An attempt to cyclize 2-Hydroxy-chalcones in dimethyl sulphoxide(DMSO)has been made.One of the methods for the synthesis of flavones,a well known class of naturally occurring compounds,involves the oxidative cyclization of 2'-hydroxychalcones.Various oxidizing agents being used include SeO_2,DDQ,I_2,HIO_4.During an attempt to cyclize 2'-hydroxychalcones using SeO_2 in DMSO,the reaction time was found to improve tremendously(from 24 to 1.5 h).