Synthesis of Thioxoquinazolin-4(3H)-one Derivatives Under Microwave and Ultrasonic Irradiation with Classical Heating

摘要

A series of thioxoquinazolin-4(3H)-one derivatives have been synthesized from hydrazide derivatives la-f using different electrophilic reagent, e.g., aryl isothibcyanate derivatives, carbon disulfide and aromatic aldehydes through nucleophilic substitution, condensation and cyclization reactions. Different methods were used to prepare compounds 2-6, including microwave irradiation, ultrasonic and classical heating. The compounds were characterized using various spectroscopic techniques. The synthesized compounds exhibited antibacterial activity.