Synthesis and Pharmacological Activities of 2,3,4,10-Tetrahydro-3,10-dioxo-2-(substitutedphenyl)-[1,2,4]triazino[4,3-a]indoles

摘要

In this study,for developing potent analgesic and antiinflammatory compounds,some new 3-substituted 1,2,4-triazino-indole derivatives have been synthesized and performed preliminary screening of their in vivo analgesic and antiinflammatory activities at a single dose of 100 mg/kg in mice by acetic acid induced writhing test and a carra-geenan induced hind paw edema model,respectively.Compounds 4b,4d and 4g exhibited good analgesic activity and compounds 4a and 4g showed very good antiinflammatory activity.