Synthesis and Antimicrobial Activity of 4H, 4-Thio-2-hepta-O-benzoyl-β-D-lactosylimino-3-phenyl-2,3-dihydro-(1,3,5)-triazino-(2,1b) 6,7 ro 8-Aryl benzothiozoles (hydrochlorides)

摘要

A series of novel 4H, 4-thio-2-hepta-O-bertzoyl-β-D-lactosylimino-3-phenyl-2,3-dihydro-(1 ,3,5)-triazino-(2, 1b) 6,7 or 8 aryl benzothiozoles (hydrochlorides) have been synthesized by the interaction of several 1-hepta-O-benzoyl-β-D-lactosyl-3-aryl benzothiozolyl thiocarbamides with N-phenyl isocyanodichloride. These compounds were screened for their antibacterial and antifungal activities agwnst-Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumonie, Psudomonas aeruginosa, Aspergillus niger and Candida atbicance. The newly synthesized compounds have been characterized by analytical and IR, ~1H NMR and mass spectral studies.