Verminous myelopathy secondary to aberrant Dirofilaria immitis migrans was detected in the cervical subarachnoid space of four dogs using MRI and CT

摘要

Aberrant Dirofilaria immitis migrans is a rare cause of neurologic signs in dogs, however, published studies describing the computed tomographic (CT) and magnetic resonance imaging (MRI) characteristics of this problem are currently lacking. The objective of this retrospective case series study was to describe the clinical and imaging findings for four adult dogs with verminous myelopathy due to aberrant Dirofilaria immitis migrans within the cervical subarachnoid space. All dogs were toy breeds, were heartworm antigen positive, had neurologic signs (ranging from cervical hyperesthesia to tetraparesis), and similar MRI findings. In two patients additionally imaged with CT, findings were variable. On MRI, each dog had a single large, dorsal- to laterally located, intradural-extramedullary, fusiform mass with characteristic stippled, mixed T2-weighted and T1-weighted signal intensity, hypo-to-iso T1-weighted signal intensity, and spinal cord compression. Nematodes were identified as serpentine or circular subarachnoid structures with low T2-weighted and T1-weighted signal in the sagittal and transverse image planes, respectively. CT (n = 2 dogs) demonstrated focal regions of mildly enhancing intradural-extramedullary spinal cord compression in 1 dog. Dorsal laminectomy and durotomy were performed in two dogs at C3-C4. A C4-5 hemilaminectomy with durotomy and dural biopsy was performed in one dog. Extraction of live, immature adult, female D. immitis worms was performed in three dogs. Operated dogs had complete post-surgical resolution of clinical signs. One dog was euthanized without surgery; necropsy revealed an adult heartworm in the spinal subarachnoid space at C2. Findings indicated that cervical spinal subarachnoid D. immitis aberrant migration should be considered as a differential diagnosis for dogs with this combination of clinical and CT/MRI imaging findings, and that the prognosis may be good with early detection and surgical removal.