An Efficient Process for The Synthesis of Anti-Obesity Drug Rimonabant

摘要

A convenient and cost effective synthetic process has been developed for the synthesis of an anti-obesity drug rimonabant(1).The process involves the condensation of 4-chloro propiophenone with diethyl oxalate to get the diketo ester(3),which upon reaction with N-amino piperidine followed by acid catalyzed cyclization with 2,4-dichloro phenyl hydrazine hydrochloride afforded rimonabant(1)in good overall yield.