Use of pi-Acceptors in Charge-Transfer Complexation of Some Cephalosporins:Chloranilic Acid as a Spectrophotometric Titrant in Non-Aqueous Media

摘要

A spectrophotometric titration method is described for the determination of some cephalosporins and their dosage forms using 0.005 M chloranilic acid solution in 1,4-dioxane as the titrant.The end-points is determined by measuring the change in absorbance of the sample at 488-528 nm.Quantitative recoveries with good reproducibility are reported for cephalexin,cefadroxile,cefaclor,cefuroxime,cefoxitin,ceftazidine and ceftriaxone eight dosage forms.The least-squares method for the end point location in the spectrophotometric titration is also proposed.