Optimization and Antifungal Activity of Chalcone Analogues

摘要

Using chalcone as a leading compound, a series of its analogues (compounds 1-16) were designed and synthesized. Their activity of antipathogenic fungi of plants has been evaluated in the laboratory. The results showed that these compounds had certain antifungal activity against Sclerotinia sclerotiorum and Botrytis cinerea. Among them, the inhibition of growth for 2-chloro-N-phenylbenzamide (compound 2) reached 92.6 and 90.1 % at a concentration of 100 mg L~(-1), respectively.