Synthesis of Admantane Substituted Spiro 1,2,4-Trioxanes Using Simple and Cheap Starting Material

摘要

Spiro 1,2,4-trioxane are synthetic derivative of artemisinin(1,2,4-trioxane is supposed to be a pharmacophore of artemisinin)which is a well known antimalarial drug from leaves of Artemisia annua found in China.Spiro 1,2,4-trioxane substituted with admantane and its 4 different derivatives were synthesized using well standardized method.These compounds were purified by simple column chromatography and successfully analyzed using ~1H NMR,IR and FAB-MS techniques.