首页> 外文期刊>Asian Journal of Chemistry: An International Quarterly Research Journal of Chemistry >Spectrophotometric Determination of Escitalopram Oxalate in Bulk and Pharmaceutical Formulations Using 7,7,8,8-Tetracyanoquinodimethane
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Spectrophotometric Determination of Escitalopram Oxalate in Bulk and Pharmaceutical Formulations Using 7,7,8,8-Tetracyanoquinodimethane

机译:用7,7,8,8-四氯三氟喹啉甲烷分光光度法测定散装和药物制剂中的草酸依西酞普兰

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摘要

The present work describes a simple and sensitive charge transfer spectrophotometric method for the determination of escitalopram oxalate in bulk and in its pharmaceutical preparations using 7,7,8,8-tetracyanoquinodimethane (TCNQ). The method is based upon a charge transfer of n-electrons from the donor moiety (7,7.8,8-tetracyanoquinodimethane) to the acceptor moiety (escitalopram). The spectrophotometric measurements were recorded by measuring the absorbance at 845 nm. The different experimental parameters were carefully studied to determine the optimal conditions for the assay procedure. Then, the method was used for the determination of escitalopram oxalate over the concentration range 4-20 ng/mL. The method was successfully applied for the determination of escitalopram oxalate in its tablets. The proposed method was compared with the reference method and was found to be equally accurate and precise.
机译:本工作描述了一种简单灵敏的电荷转移分光光度法,用于测定散装的依他普仑草酸盐及其药物制剂中的7,7,8,8-四氰基喹二甲烷(TCNQ)。该方法基于n-电子从供体部分(7,7.8,8-四氰基喹二甲烷)到受体部分(依他普仑)的电荷转移。通过测量845nm处的吸光度来记录分光光度测量。仔细研究了不同的实验参数,以确定测定程序的最佳条件。然后,该方法用于测定4-20 ng / mL浓度范围内的草酸依地普仑。该方法已成功地用于片剂中草酸艾司西酞普兰的测定。将该方法与参考方法进行了比较,发现该方法同样准确,精确。

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