Hexadecylphosphocholine: Skin Treatment of Cutaneous leishmania

摘要

Human leishmaniasis is a parasitic disease caused by trypnosomatid of the genus leishmania,transmitted by the bite of a sand fly of genus phlebotomus,a characteristic of all leishmanial infections in the intracellular parasitism of macrophages. Various species of leishmania have been identified causing the disease ranging from simple cutaneous to Visceral leishmaniasis. Hexadecylphosphocholine (HePC),a novel phospholipids derivative,was tested against leishmania major and leishmania tropica,the causative agent of Cutaneous leishmaniasis. Human volunteer were cured completely,when treated topically with an ointment comprising 15 % HePC and 12 % methyl benzethonium chloride in simple ointment base twice daily for 10 d. No parasites were detected in tissue smears or in culture from treated cutaneous lesions.