We have observed thai nonderivatized C60(buckminsterfullerene) could inhibit the replication of simian immunodeficiency virus (SIV) in vitro and the activity of Moloney murine leukemia virus (M-MuLV) reverse transcriptase (RT) (IC50≈3 μM). This means that biological effects are exerted via a direct and active interaction of the C6oskeleton with other macromolecules.
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