Regioselectivity in Benzylation of Chrysin

摘要

A regioselective monobenzylation of the 7-hydroxyl group of 5,7-dihydroxy fiavone (I) under extremely mild basic conditions (anhydrous NaHCO3) and polar solvent (CH3CN) has been developed. The selective debenzylation of 5,1-bis benzyloxy flavone (III) to obtain 7-benzyloxy-5-hydroxy fiavone (II) is also reported.