Defining components required for transport from the ER to the golgi complex in yeast

摘要

AbstractSeveral complementary approaches have been fruitful in the study of transport from the ER to the Golgi complex in yeast. Mutational analysis has led to the identification of genes required for this process, many of which are now being studied at the molecular and biochemical level. In the case ofSEC18, DNA sequence analysis has demonstrated homology to a factor needed for transport in mammalianin vitrosystems. In addition, the events that take place at this stage of the secretory pathway have been reconstitutedin vitro.