Localization of human ARF2 and NCK genes and 13 otheriNot/il-linking clones to chromosome 3 by fluorescence in situ hybridization

摘要

Two human genes containing Notl sites, ADP-ribosylation factor (ARF2) and melanoma NCK protein, were mapped by fluorescence in situ hybridization to 3p21.2→ p21.1 and 3q21, respectively. Thirteen other NotI linking clones, representing sequence tagged sites, were also mapped to different regions of human chromosome 3. Two of these clones that contain sequences 80% homologous to the rat tropoelastin gene and brain Cl–/sup> channel protein CLC-2 gene probably represent new human genes closely related to the known rat ge