Hepatoprotective effects of camel milk against CCl_4-induced hepatotoxicity in rats

摘要

Camel milk has been widely used in a number of countries as a food additive and for curing some commonly occurring diseases. Recently, camel milk has been deeply studied for its special properties because of higher hepatoprotective, insulin like and antibacterial activities. These properties distinguish camel milk from milk of other animals. The present study was carried out to investigate the protective effects of camel milk against CCl_4-induced hepatotoxicity which lead to biochemical alterations in liver function of male albino wister rats. White albino male rats (200-250 g) were divided into 5 groups, a normal control water group, a control camel milk group and three CCl_4-intoxicated groups treated with or without camel milk. Protective roles of camel milk were analyzed by assaying the liver function parameters as serum aminotransferases, alkaline phosphatase, serum proteins and cholesterol levels. Histopathological examinations were also studied in all groups of rats by microscopy. Data showed that intraperitoneal administration of CC1_4 (1 mL kg~(-1) b.wt.) resulted in statistically significant increase in the serum levels of aminotransferases and change in serum protein, albumin and cholesterol levels which approach to normal levels after the treatment with raw camel milk. Furthermore, histopathological studies reveal that camel milk treatments significantly reduce the incidence of liver lesions induced by CC1_4. Our findings demonstrate that CC1_4 exposure alters liver function biochemical parameters, which shift towards normal values after treatment with camel milk. So camel milk has a good potent for curing some liver diseases.