The chemistry and biological activity of a new class of azole fungicides: 1‐amino‐1,2,4‐triazoles

摘要

AbstractThe fungicidal activity of a novel class of triazole compounds in which the 1‐position of the azole nucleus is bonded to a nitrogen atom was investigated. Such 1‐amino‐1,2,4‐triazoles are amenable to great structural variation which allows the elucidation of the requirements for biological activity. As in most other triazole fungicides, the basic structural requirement for activity is a two‐atom bridge connecting the azole nucleus to a hydrophobic group, typically an aromatic ring. The synthesis and optimization of fungicidal activity of this class of triazole fungicide are