Comparison of the analgesic effects of meloxicam with those of ketoprofen in male stray dogs undergoing pinhole castration.

摘要

The adequacy of analgesia using meloxicam and ketoprofen was assessed in 12 male stray dogs following pinhole castration. The analgesics were started preemptively and repeated daily up to 72 h post castration. The study was conducted under blind conditions. The pain assessment was made adopting "The University of Melbourne Pain Scale" (UMPS) preoperatively and at 06, 12, 18, 24, 36, 48, 60, 72, 84 and 96 h post operatively. Mean+or-SD total pain score values in animals of meloxicam group were highest MTPS (7.5) at 48 h but in animals of ketoprofen group the highest score (8.3) was recorded at 12 and 24 h following castration. In both the groups, lowest values (3.5, 2.7, respectively) were obtained preoperatively (0 h). The values in both the groups were significantly (p<0.05) higher continuously from 6 to 84 h following castration and showed decreasing trend towards the end of observation period. The values obtained at the last observation period (96 h) was slightly more and equal in both the groups than the values obtained preoperatively. Between the groups, the values did not differ significantly (p>0.05) at any time interval. The dogs were maintained for one month and were watched for any complications and adverse reactions of the analgesic drugs used. Vomiting, diarrhea or gross evidence of fecal blood did not occur in any of the dogs throughout the study period. In summary both drugs provided good and similar analgesia. However, administration of one more dose of the analgesic is recommended at 96 h post ligation.CAS Registry Numbers 22071-15-4