T and NK cells collaborate to control viral infections, discerning minute differences between infected and uninfected cells. At the same time, viruses have evolved to escape this discovery. In this issue of the JCI, Ganem and colleagues show that Kaposi sarcoma-associated herpesvirus (KSHV) inhibits CD1d presentation to T cells. This novel immune evasion strategy highlights the importance of CD1d-restricted T cells in controlling viral infection and raises an interesting question: how do T cells recognize viruses in the context of CD1 molecules that bind lipids? In the case of herpesviruses, alterations in endosomal trafficking might trigger redistribution of CD1/lipid complexes to cell surfaces, thereby promoting recognition by CD1d-restricted T cells.
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机译：T细胞和NK细胞协同控制病毒感染，辨别感染和未感染细胞之间的微小差异。与此同时，病毒已经进化到逃避这一发现。在本期JCI中，Ganem及其同事表明，卡波西肉瘤相关疱疹病毒（KSHV）抑制CD1d呈递给T细胞。这种新的免疫逃避策略强调了CD1d限制性T细胞在控制病毒感染中的重要性，并提出了一个有趣的问题：T细胞如何在结合脂质的CD1分子的背景下识别病毒？在疱疹病毒的情况下，内体运输的改变可能会触发 CD1/脂质复合物重新分布到细胞表面，从而促进 CD1d 限制性 T 细胞的识别。
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