Ligand- and Base-Free Cu-Catalyzed C-N Coupling of Aminoquinolines with Boronic Acids

摘要

A ligand- and base-free Cu-catalyzed protocol for the synthesis of N-arylquinolin-8-amine and N-arylquinolin-3-amine derivatives has been developed. A wide range of N-aryl heterocycles were synthesized in moderate to good yields under the mild condition of 10 mol% Cu(OAc)(2) in 3 mL methanol at room temperature in presence of air.