KCa1.1 Inhibition Attenuates Fibroblast-like Synoviocyte Invasiveness and Ameliorates Disease in Rat Models of Rheumatoid Arthritis

摘要

Objective. Fibroblast-like synoviocytes (FLS) participate in joint inflammation and damage in rheumatoid arthritis (RA) and its animal models. The purpose of this study was to define the importance of KCa1.1 (BK, Maxi-K, Slo1, KCNMA1) channel expression and function in FLS and to establish these channels as potential new targets for RA therapy.