Regional assignment of the mouse αA2-crystallin gene (iCrya-/ii1/i) to chromosome 17A3→B by in situ hybridization

摘要

Previously, we assigned the αA2-crystallin (Crya-1) structural gene to mouse chromosome 17 via Southern blot hybridization analysis of mouse × Chinese hamster somatic cell hybrids. Using in situ hybridization, we have now localized this gene to 17A3→B, a subchromosomal region containing several genes whose linkage relationships have been shown to be conserved on human chromosome 6. In man, however, the homologous gene (CRYA1) is located on human chromosome 21, indicating that internal rearrangements can occur within highly conserved chromosomal regions during the divergence of man and mo