Research Advancement in RV Novel Vaccine

摘要

In this study, we reviewed the international research progress on the novel vaccines of rabies. Rabies is a lethal infectious disease, causing nearly 55,000 deaths worldwide each year. To date, pre-exposure vaccination is the most effective method to prevent rabies. As most of rabies cases occurred in developing countries, it is necessary develop vaccines that are inexpensive; furthermore, eradicating of rabies in wildlife calls for one single injection of vaccine. In the present study, vaccines employed for vaccination, including inactivated vaccines, subunit vaccine, DNA vaccine and newly attenuated vaccine are reviewed. In addition, viewpoints about development trends of vaccines are also discussed here. Since, rabies virus has wide range of reservoirs and vaccines now used is targeted to specific animal; in addition, the potential of reversion to pathogenic rabies virus makes it urgent need to develop new types of vaccines applying to different kinds of animal species. Also, new vaccines must be able to confer protective immunity with one single immunization of vaccines, because of difficulty in finding rabies virus reservoir for booster vaccinations.