A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

Vieira Angelica T.; Macia Laurence; Galvao Izabela; Martins Flaviano S.; Canesso Maria Cecilia C.; Amaral Flavio A.; Garcia Cristiana C.; Maslowski Kendle M.; De Leon Ellen; Shim Doris; Nicoli Jacques R.; Harper Jacquie L.; Teixeira Mauro M.; Mackay Charles R.

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A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

机译：肠道菌群和代谢物受体GPR43在痛风小鼠模型中的作用。

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Objective. Host-microbial interactions are central in health and disease. Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1 (IL-1) production and neutrophil recruitment. This study was undertaken to investigate the relevance of gut microbiota, acetate, and the metabolite-sensing receptor GPR43 in regulating inflammation in a murine model of gout.

机译：目的。宿主与微生物的相互作用在健康和疾病中至关重要。一水合尿酸一钠（MSU）晶体通过激活NLRP3炎性小体而引起痛风，导致白介素1（IL-1）的产生和嗜中性白细胞的募集。这项研究旨在研究肠道微生物群，乙酸盐和代谢物受体GPR43在调节痛风小鼠模型中的炎症反应中的相关性。

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《Arthritis & rheumatology.》 |2015年第6期|共11页
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Vieira Angelica T.; Macia Laurence; Galvao Izabela; Martins Flaviano S.; Canesso Maria Cecilia C.; Amaral Flavio A.; Garcia Cristiana C.; Maslowski Kendle M.; De Leon Ellen; Shim Doris; Nicoli Jacques R.; Harper Jacquie L.; Teixeira Mauro M.; Mackay Charles R.;
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正文语种 eng
中图分类全身性疾病;
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1. A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout [J] . Vieira Angelica T., Macia Laurence, Galvao Izabela, Arthritis & rheumatology. . 2015,第6期

机译：肠道菌群和代谢物受体GPR43在痛风小鼠模型中的作用。
2. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome [J] . Laurence Macia, Jian Tan, Angelica T. Vieira, Nature Communications . 2015,第1期

机译：代谢物感应受体GPR43和GPR109A通过调节炎症小体促进膳食纤维诱导的肠道稳态
3. The gut microbiota suppresses insulin-mediatedfat accumulation via the short-chain fatty acidreceptor GPR43 [J] . Ikuo Kimura, Kentaro Ozawa, Daisuke Inoue, Nature Communications . 2013,第May期

机译：肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪蓄积
4. The Role of the Gut Microbiome on Mercury Toxicology: Protein-Rich Diet Alters Gut Microbiota Composition and Increases Methylmercury Demethylation [C] . Galen Guo, Emmanuel Yumvihoze, Laurie Chan, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：肠道微生物组对汞毒理学的作用：富含蛋白质的饮食改变肠道微生物群组成并增加甲基汞去甲基化
5. The Short Chain Fatty Acid Receptor, Free Fatty Acid-2 Receptor (FFA2), Contributes to Gestational Glucose Homeostasis through a Novel Relationship Between Pancreatic Beta Cells, Short Chain Fatty Acids and the Gut Microbiota. [D] . Fuller, Miles Henry. 2016

机译：短链脂肪酸受体，游离脂肪酸2受体（FFA2）通过胰腺β细胞，短链脂肪酸和肠道菌群之间的新关系，有助于妊娠期葡萄糖体内稳态。
6. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43 [O] . Ikuo Kimura, Kentaro Ozawa, Daisuke Inoue, -1

机译：肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪积聚
7. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43 [O] . Kimura Ikuo, Ozawa Kentaro, Inoue Daisuke, 2013

机译：肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪积聚

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

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