The Foot-and-mouth Disease (FMD), which is the most devastating disease of livestock husbandry, drastically hinders the development of stock raising. At present the main FMD vaccine is still traditional inactivated vaccine, as its good performance in protective activity and immune efficacy, it is widely used in the world for preventing and controlling this disease, especially in developing countries. However, people have realized many disadvantages of inactivated vaccine. In order to resolve these problems, the scientists are conducting some new research about novel FMD vaccine to seek for more secure and effective vaccines. Nowadays, with the rapid development of molecular biology, researchers are paying high emphasis on novel FMD vaccines, such as, synthetic peptide vaccine, epitope-based vaccine, DNA vaccine, chimeric vaccine and so on. There is no doubt that these new-type FMD vaccines will make great contribution to the prevention and control of FMD. This study reviewed the international research progress on the traditional vaccines and novel vaccines of FMD.
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