Distribution and metabolism of C-14-resveratrol in human prostate tissue after oral administration of a 'dietary-achievable' or 'pharmacological' dose: what are the implications for anticancer activity?

摘要

Background: The dietary polyphenol resveratrol prevents various malignancies in preclinical models, including prostate cancer. Despite attempts to translate findings to humans, gaps remain in understanding pharmacokinetic-pharmacodynamic relations and how tissue concentrations affect efficacy. Such information is necessary for dose selection and is particularly important given the low bioavailability of resveratrol.