Proceedings of the conference 'Lymphocyte development, tolerance and autoimmunity: solved and open questions', held at the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, on May 12, 2011 (Wroclaw, Poland) : lymphocyte development, tolerance and autoimmunity: a personal perspective.

摘要

Understanding the mechanisms of the immunological tolerance and autoimmunity remains a major challenge for researchers and clinicians struggling to free the society from several serious diseases (e.g., diabetes), which result from the disturbance of the regulatory mechanisms maintaining properly functioning immune system. Often these disturbances have their origin in impaired lymphocyte development, therefore, the prospect for the progress in fighting autoimmune diseases or breaking tolerance to the tumors is very much dependent on the better understanding of the mechanisms of lymphocyte development and their functional diversification.