7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by 2 nicotinic ACh receptor activation

摘要

Background and PurposeDisruptions of executive function, including attentional deficits, are a hallmark of a number of diseases. ACh in the prefrontal cortex regulates attentive behaviour; however, the role of 7 nicotinic ACh receptor (7nAChR) in attention is contentious.