Hemoglobin-based oxygen carrier attenuates cerebral damage by improving tissue oxygen preload in a dog model of cardiopulmonary bypass

摘要

In order to investigate whether hemoglobin-based oxygen carrier (HBOC) attenuates cardiopulmonary bypass (CPB)-induced cerebral damage. Male adult Beagle dogs were randomly divided into sham, control, and HBOC groups. After establishment of CPB model, hearts were arrested for 2 h and reperfused for 2 h. HBOC improved intracerebral O-2 tensions and reduced the releases of biomarkers for cerebral damage, including neuron-specific enolase and S100 beta in both cerebrospinal fluid and serum. Moreover, HBOC attenuated the releases of tumor necrosis factor-alpha and interleukin-1 beta after CPB. Therefore, our findings suggest that HBOC could reduce cerebral damage after CPB, which was probably associated with improvement of tissue O-2 preload.