Response to Morfeld (2013): Second commentary to Gebel 2012 - Established use of cancer potency indices and biological plausibility

摘要

The evaluations in Gebel (Arch Toxicol 86(7):995-1007, 2012) were carried out according to established procedures in regulatory toxicology. The variability in the available data was taken into account. The quality of the underlying data set should not be overestimated. The relevant conclusion in Gebel (Arch Toxicol 86(7):995-1007, 2012) is that the difference in carcinogenic potency comparing nanosized to microsized respirable granular biodurable particles without known significant specific toxicity (GBP) is low and lower than previously estimated.