A taylor-made linear dimer was synthesized starting from lithocholic acid,an inexpensive steroid bile acid.The presented route uses the Yamaguchi reaction for attaching an unsaturated acid to the methyl lithocholate ester.Linking of two lithocholate ester derivatives was performed via the Grubbs' ruthenium catalyzed olefin cross-metathesis.Possible applications of tiiis coupling strategy include development of bile acid based polymers for use as biocompatible prosthetic devices and drug delivery systems.Examples of oligomers having these potential applications can be found in the recent literature.
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