Endotoxin tolerance induction in human periodontal ligament fibroblasts stimulated with different bacterial lipopolysaccharides

摘要

Objective: Human periodontal ligament fibroblasts (hPDLFs) may play an important role in immune responses in the periodontal microenvironment by secreting proinflammatory cytokines. The present study aimed to explore the reaction of hPDLFs to a secondary lipopolysaccharide (LPS) challenge by examining cytokines and innate sensors.