PATHOGENICITY OF INFLUENZA A/SEAL/MASS/1/80 VIRUS MUTANTS FOR MAMMALIAN SPECIES

摘要

Increases in infectiousness, neurotropism and virulence were found in a laboratory variant of influenza A/Seal/Massachussets/1/80 (H7N7) virus having a highly cleavable hemagglutinin. Sequential passage from host to host further increased pathogenicity of the H7N7 virus in mice, ferrets and rats.