Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes

摘要

DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSFIR, and SRC protooncogene loci; the retinoblastoma gene locus (RBI); the tumor virus integration sites INT2, PVT1, and MLVI2; and the locus of the tumor-specific antigen T1A were used to screen mouse genomic DNAs from RF/J, CAST/Ei, MOLF/Ei, Mus musculus musculus, M. m. poschiavinus, and M. spretus. Polymorphic DNA fragments for the 18 DNA probes have been identified using Southern blot hybridization and restriction fragment length polymorphism (RFLP) analysis.