GMP - GOOD MODELLING PRACTICE - AN ESSENTIAL COMPONENT OF GOOD MANUFACTURING PRACTICE

摘要

There is much interest in the exploitation of more-or-less sophisticated mathematical methods combining the signals from different sensors for measured variables for estimating the present or future state of bioprocesses. In many cases, however, the application of these methods has failed to take into account many important principles. We therefore summarize what we consider to be some of the key issues, and present them in the form of a guide for assisting the development of these methods and their integration into mainstream biotechnology.