S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic beta-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing beta-Cell Function in Male Mice

摘要

Background: S-equol, which is enantioselectively produced from daidzein by gut microbiota, has been suggested as a chemopreventive agent against type 2 diabetes mellitus (T2DM), but the underlying mechanisms remain unclear.