Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial

Burmester Gerd-Rudiger; Kivitz Alan J.; Kupper Hartmut; Arulmani Udayasankar; Florentinus Stefan; Goss Sandra L.; Rathmann Suchitrita S.; Fleischmann Roy M.

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Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial

机译：甲氨蝶呤剂量加阿达木单抗联合治疗的有效性和安全性：CONCERTO随机试验

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Objective CONCERTO was a randomised, double-blind, parallel-armed study of methotrexate (MTX) in combination with adalimumab to assess whether an increasing trend of efficacy and decreased safety exists when increasing MTX dose in patients with early rheumatoid arthritis (RA).

机译：目的CONCERTO是甲氨蝶呤（MTX）与阿达木单抗联合的一项随机，双盲，平行研究，旨在评估早期类风湿关节炎（RA）患者在增加MTX剂量时是否存在疗效增加和安全性降低的趋势。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2015年第6期|共8页
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Burmester Gerd-Rudiger; Kivitz Alan J.; Kupper Hartmut; Arulmani Udayasankar; Florentinus Stefan; Goss Sandra L.; Rathmann Suchitrita S.; Fleischmann Roy M.;
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正文语种 eng
中图分类免疫性疾病;
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入库时间 2022-08-18 10:16:36

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1. Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial [J] . Burmester Gerd-Rudiger, Kivitz Alan J., Kupper Hartmut, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2015,第6期

机译：甲氨蝶呤剂量加阿达木单抗联合治疗的有效性和安全性：CONCERTO随机试验
2. Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial [J] . Fleischmann Roy, Mysler Eduardo, Hall Stephen, The Lancet . 2017,第10093期

机译：TOFACITINIB单药治疗的疗效和安全性与甲氨蝶呤和甲氨蝶呤的甲氨蝶呤和甲氨蝶呤甲氨蝶呤（口腔策略）：A相3B / 4，双盲，头部到头，随机对照试验
3. Comparative efficacy and safety of biosimilar adalimumab and originator adalimumab in combination with methotrexate in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials [J] . Bae Sang-Cheol, Lee Young Ho Clinical rheumatology . 2018,第5期

机译：生物仿生毒率和发起剂Adalimalab与活性类风湿性关节炎患者结合甲氨蝶呤的比较疗效和安全性：随机对照试验的贝叶斯网络荟萃分析
4. Efficacy and safety of a two dose one bottle porcine circoims/Mycoplasma hyopneumoniae combination vaccine [C] . J. W. Bubolz, D. S. Fredrickson, V.J. Rapp-Gabrielson, Annual^Meeting of the American Association^of^Swine^Veterinarians. . 2014

机译：两剂量的疗效和安全性，一瓶瓶猪圈 IMS / mycoplasma yecopneumoniae组合疫苗
5. Sample size determination for Emax model, equivalence/non-inferiority test and drug combination in fixed dose trials. [D] . Wang, Jie. 2008

机译：在固定剂量试验中确定Emax模型，等效性/非劣效性试验和药物组合的样本量。
6. Extended report: Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial [O] . Gerd-Rűdiger Burmester, Alan J Kivitz, Hartmut Kupper, -1

机译：扩展报告：甲氨蝶呤剂量联合阿达木单抗的疗效和安全性：CONCERTO随机试验
7. Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial [O] . Gerd-Rűdiger Burmester, Alan J Kivitz, Hartmut Kupper, 2014

机译：甲氨蝶呤剂量与Adalimalab联合的疗效和安全性：随机协奏曲试验

Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial

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