Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

Sieper Joachim; Braun Juergen; Kay Jonathan; Badalamenti Salvatore; Radin Allen R.; Jiao Lixia; Fiore Stefano; Momtahen Tanya; Yancopoulos George D.; Stahl Neil; Inman Robert D.

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Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

机译：Sarilumab用于治疗强直性脊柱炎：II期，随机，双盲，安慰剂对照研究（ALIGN）的结果

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Objectives The ALIGN study (NCT01061723) evaluated the efficacy and safety of sarilumab, the first fully human monoclonal antibody against interleukin-6 receptor- (IL-6R), in patients with ankylosing spondylitis (AS).

机译：目的ALIGN研究（NCT01061723）评估了sarilumab，即第一种抗白介素6受体（IL-6R）的完全人类单克隆抗体在强直性脊柱炎（AS）患者中的疗效和安全性。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2015年第6期|共7页
作者
Sieper Joachim; Braun Juergen; Kay Jonathan; Badalamenti Salvatore; Radin Allen R.; Jiao Lixia; Fiore Stefano; Momtahen Tanya; Yancopoulos George D.; Stahl Neil; Inman Robert D.;
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正文语种 eng
中图分类免疫性疾病;
关键词
Ankylosing Spondylitis; Cytokines; DMARDs (biologic); Autoimmune Diseases; Inflammation;

机译：强直性脊柱炎;细胞因子;DMARDs（生物的）;自身免疫性疾病;炎症;
入库时间 2022-08-18 10:16:36

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1. Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN) [J] . Sieper Joachim, Braun Juergen, Kay Jonathan, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2015,第6期

机译：Sarilumab用于治疗强直性脊柱炎：II期，随机，双盲，安慰剂对照研究（ALIGN）的结果
2. Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase IIb, randomised, double-blind, placebo-controlled, dose-ranging study [J] . van der Heijde Desiree, Gensler Lianne S., Deodhar Atul, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2020,第5期

机译：白细胞介素-17a和白细胞介素-17f的双重中和患者在有源强直性脊柱炎患者中：48周的IIb，随机，双盲，安慰剂控制，剂量测量研究的结果
3. Phase III, multi-centre, randomised, double blind, Placebo-controlled study for treatment of juvenile ankylosing spondylitis (AS) with Adalimumab [J] . G Horneff, S Fitter, HI Huppertz, Pediatric rheumatology online journal . 2011,第S1期

机译：III期，多中心，随机，双盲，安慰剂对照研究，使用阿达木单抗治疗青少年强直性脊柱炎（AS）
4. MULTI-CENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED STUDY OF ORAL TOCERANIB PHOSPHATE (PALLADIATM, SU11654), A RECEPTOR TYROSINE KINASE INHIBITOR, FOR THE TREATMENT OF DOGS WITH RECURRENT MAS [C] . Cheryl L London, Carolyn J Henry, Anthony W Rusk, Annual conference of the Veterinary Cancer Society . 2008

机译：多中心，安慰剂对照，双盲，随机研究口服Toceranib磷酸盐（Palladia TM，SU11654），受体酪氨酸激酶抑制剂，用于治疗经常性MAS的狗
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. Extended report: Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II randomised double-blind placebo-controlled study (ALIGN) [O] . Joachim Sieper, Jürgen Braun, Jonathan Kay, -1

机译：扩展报告：Sarilumab用于治疗强直性脊柱炎：II期随机双盲安慰剂对照研究（ALIGN）的结果
7. Faculty Opinions recommendation of Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN). [O] . Pedro Machado 2020

机译：Sarilumab建议治疗强直性脊柱炎的教师意见：II期结果，随机，双盲，安慰剂对照研究（对齐）。

Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

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