Rearrangements of T cell receptor loci can be found only rarely in B lymphoid cells

摘要

AbstractWe have studied the rearrangement status of the T cell receptor genes in 64 B lymphoid cell lines, and we found that, unlike the immunoglobulin heavy chain genes in T lymphocytes, T cell Receptor β and related γ chain genes are almost always in germ‐line configuration in B lymphoid cells. The only exception was a myeloma MOPC511 (IgA,x) which contained all T cell receptor genes, β1, β2, γ1, γ2, γ3, and α, in rearranged configuration in both homologous chromosomes. This exception supports the concept that all immunoglobulin and T cell receptor genes exploit the same recombinase to build their complete variable regions. Obviously, in MOPC511 cells the regulation, which confers the tissue specificityi.e.Tvs.B lymphocytes, h