Combination therapy with ciclosporin and etanercept in patients with psoriatic arthritis.

摘要

Psoriatic arthritis (PsA) is a heterogeneous disease involving the musculoskeletal structures; the skin and nails. Traditional disease-modifying antirheumatic drugs and tumour necrosis factor a (TNFa) antagonists are effective on cutaneous and articular manifestations of psoriatic disease. Most patients with PsA are successfully treated with TNFa antagonists. However, a subset of patients with PsA are not responsive to these treatments or do not maintain a clinical response to the cutaneous manifestations despite the remission of arthritis.