Two new sesquiterpenoids from endophytic fungus J3 isolated from Mangrove Plant Ceriops tagal

摘要

Two new sesquiterpenoids, named 2 alpha-hydroxyxylaranol B (1) and 4 beta-hydroxyxylaranol B (2), together with a known diterpenoid 3,4-seco-sonderianol (3) were isolated from the fermentation of endophytic fungus J3 of Ceriops tagal. Their structures were elucidated based on spectroscopic methods including 1D and 2D NMR (HMQC, H-1-H-1 COSY and HMBC). All compounds were evaluated for their cytotoxic activities by MTT method, and compound 3 exhibited cytotoxic activities against K562, SGC-7901, and BEL-7402 cell lines.