Black tea extract improves anti-oxidant profile in experimental diabetic rats

摘要

Objective: The purpose of this study was to investigate the in vivo anti-oxidant effect of black tea extract (BTE) supplemented to normal and alloxan-induced diabetic rats. Methods: Black tea extract (BTE) was fed to control and experimental diabetic rats by gavage technique at a dose of 1 ml/100 g body weight/day. Markers of oxidative stress in blood were determined. Result: Results show a significant (P < 0.01) decrease (73%) in plasma anti-oxidant potential, increase in activity of plasma membrane redox system (122%), protein oxidation and lipid peroxidation in diabetic rats, BTE supplemented diabetic rats had improved anti-oxidant profile and lower protein and lipid peroxidation levels. Diabetic rats displayed lower intracellular glutathione (GSH), BTE supplementation improved GSH levels. Conclusion: Results of this study suggest that the 2.5% aqueous extract of black tea is effective to ameliorate diabetes associated oxidative stress parameters in experimental model of diabetes.