Evaluation of HER2eu Status by Immunohistochemistry Using Computer-Based Image Analysis and Correlation With Gene Amplification by Fluorescence In Situ Hybridization Assay

摘要

Context.-The American Society of Clinical Oncology/College of American Pathologists proposed several recommendations for human epidermal growth factor receptor 2 (HER2) test standardization. One suggestion was that image analysis (IA) could be useful for scoring of HER2eu immunohistochemistry. The utilization of IA in a real-world practice in a large cohort of cases has not been previously reported.