Exploratory study on oxygen consumption on-kinetics during treadmill walking in women with systemic lupus erythematosus.

摘要

OBJECTIVE: To determine whether oxygen consumption (V o(2)) on-kinetics differed between groups of women with systemic lupus erythematosus (SLE) and sedentary but otherwise healthy controls. DESIGN: Exploratory case-control study. SETTING: Medical school exercise physiology laboratory. PARTICIPANTS: Convenience samples of women with SLE (n=12) and sedentary but otherwise healthy controls (n=10). INTERVENTION: None. MAIN OUTCOME MEASURES: V o(2) on-kinetics indices including time to steady state, rate constant, mean response time (MRT), transition constant, and oxygen deficit measured during bouts of treadmill walking at intensities of 3 and 5 metabolic equivalents (METs). RESULTS: Time to steady state and oxygen deficit were increased and rate constant was decreased in the women with SLE compared with controls. At the 5-MET energy demand, the transition constant was lower and MRT was longer in the women with SLE than in controls. For a similar relative energy expenditure that was slightly lower than the anaerobic threshold, the transition constant was higher in controls than in women with SLE. CONCLUSION: V o(2) on-kinetics was prolonged in women with SLE. The prolongation was concomitant with an increase in oxygen deficit and may underlie performance fatigability in women with SLE.