AN IMPROVED SYNTHESIS OF 2-n-(PROPYL)-1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID DIETHYL ESTER

摘要

Diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate (4) is an intermediate in the synthesis of olmesartan,a non-peptide angiotensin II receptor antagonist.Yanagisawa et al.reported using diaminomaleonitrile and trimethyl orthobutyrate as starting materials.