Impact of parainfluenza virus type 3 infection on engraftment after hematopoietic SCT

摘要

Human parainfluenza virus type 3 (PIV3) can cause severe morbidity and mortality among haematopoietic stem cell transplant (HSCT) recipients. In fact, studies have reported mortality rates of up to 40-50% in adult HSCT patients with PIV3-related pneumonia. Previous reports, however, have focussed almost entirely on the pulmonary manifestations of PIV3 infection in the HSCT population. Extra-pulmonary manifestations of PIV3 infection are rare, but can include meningitis, myopericarditis and parotitis. We report here a nosocomial outbreak of PIV3 involving HSCT recipients, and describe associated haematologic manifestations, including loss of engraftment in severely affected patients.