Primary amines as new carbonyl surrogate in Kabachnik-fields reaction: A new metal free one pot approach to synthesize α-Aminophosphonates in water

摘要

A new and green strategy to synthesize α-aminophosphonates has been developed using benzyl amines as carbonyl alternates. The method involves oxidative deamination of benzyl amines to produce in situ aldehyde intermediate which is then directly converted into aminophosphonates by coupling with aryl amines and trialkylphosphite. The synthesis offers a green alternative strategy which involves benzyl amines as useful carbonyl surrogate and their possible application in multi-component reactions to synthesize value added products like aminophosphonates. The methodology has a wide substrate scope and functional group compatibility. Further, the synthesis uses aqueous hydrogen peroxide (H2O2) as a green oxidant and enables to synthesize these products under mild and metal-free conditions in water as a medium.