Microwave Assisted Synthesis of 2,3-Dihydro-4Hfuro 2,3-dpyrido1,2-apyrimidin-4-ones and furo2,3-dpyrido1,2-apyrimidin-4-one

摘要

Kocaeli University, Kabaoglu, 41380, In this work, furo2,3- dpyrido1,2-apyrimidin-4-ones were obtained by microwave assisted radical cyclizations of 2-hydroxy-4H-pirido1,2- apirimidin-4-ones with conjugated alkenes and phenylacetylene via Mn(OAc)3. Conventional heating and microwave irradiated reaction types were compared using parameters like temperature, time and molar ratios to determine best reaction condition. Obtained compounds were purified by chromatographic methods and characterized by spectroscopic techniques (1HNMR, 13CNMR, HRMS, FTIR). Also, to determine the exact configuration and regioselectivity of isolated compounds, XRD analysis were performed.